Custom Peptides
Cayman Chemical -2-Methyl ArachIdonyl-2- 10mg
An analog of AEA in which the alcohol of the ethanolamide group has been replaced with a fluorine atom, which increases the binding affinity and selectivity for the CB1 receptor (Ki = 5.7 nM in rat brain); in vivo activity is enhanced much less than the binding affinity, because the analog is rapidly hydrolyzed by AEA; the addition of an α-methyl group at the C-2 position of arachidonic acid confers enhanced metabolic stability; can fully substitute for Δ9-THC in animal self-administration tests, whereas AEA and 2-fluoro AEA cannot
Cayman Chemical MethylpIperIdIno pyrazole 10mg
A highly selective ERα receptor antagonist (Ki = 5.6 nM; IC50 = 80 nM)
Cayman Chemical ArtemIsInIc AcId 10mg
A sesquiterpene; decreases triglyceride levels and GPDH activity in hAMSCs; inhibits adipocyte differentiation at 200 µM; decreases C/EBPα and HMG-CoA reductase mRNA expression and inhibits cholesterol synthesis and melanogenesis in human epidermal melanocytes
Cayman Chemical ncrostatIn-1 10mg
An inhibitor of RIP1 kinase that prevents the death of TNF-α-treated FADD-deficient Jurkat cells with an EC50 value of 490 nM
Cayman Chemical BYK 191023hydrochlorIde 10mg
A selective iNOS inhibitor (IC50s = 0.086, 17, and 162 μM for human recombinant iNOS, nNOS, and eNOS, respectively); inhibits iNOS-induced nitrite generation in RMC, RAW, and HEK293 cells (IC50s = 33, 3.1, and 13 μM, respectively); suppresses LPS-induced increases in plasma nitrate and nitrite levels in rats (ED50 = 14.9 μmol/kg per hour); prevents development of delayed hypotension in a rat model of LPS-induced endotoxemia at 50 μmol/kg per hour; increases mean arterial pressure and renal blood flow in a sheep model of septic shock
Cayman Chemical TrequInsInhydrochlorIde 10mg
A cAMP-dependent PDE3 inhibitor (IC50s = 0.04 and 0.03 nM for PDE3A and PDE3B, respectively in T84 cell lysates); stimulates cAMP accumulation (10 µM) and increases membrane capacitance in rat juxtaglomerular cells; competitively inhibits multidrug resistant protein 5-mediated export of cGMP from Chinese hamster lung fibroblasts (Ki = 240 nM); reduces collagen-induced platelet aggregation in rabbits (3 UG/kg per minute); reduces collagen-induced decreases in mean arterial blood pressure alone or in combination with prostacyclin
Cayman Chemical 1MyrIstoyl2Oleoyl3Docosa 10mg
A triacylglycerol; has been used as a reagent to study the regioselectivity of thermal chlorination reactions between triacylglycerols and organochlorines that result in the formation of MCPD diesters
Cayman Chemical DerazntInIb 10mg
A multi-kinase inhibitor; a pan inhibitor of FGFR (IC50s = 4.5, 1.8, 4.5, and 34 nM for FGFR1, -2, -3, and -4, respectively); inhibits 18 tyrosine kinases and the calcium/calmodulin-dependent protein kinase QIK in a panel of 297 kinases (IC50s = 3-31 and 9.7 nM, respectively); decreases phosphorylation of FGFR in COS-1 cells expressing FGFR1, -2, -3, or -4 (IC50s = 10 µM, respectively) and inhibits the growth of 15 cancer cell lines with mutant, amplified, or translocated FGFR (GI50s = 0.1-1.7 µM); reduces tumor growth and decreases tumor protein levels of phosphorylated FGFR, FRS2, and ERK in a SNU-16 mouse xenograft model at 50 and 75 mg/kg
Cayman Chemical 1 2DIoleoylsnglycero3PG 10mg
A phospholipid containing the long-chain (18:1) fatty acid oleic acid inserted at the sn-1 and sn-2 positions
Cayman Chemical DIhydrolycorIn 10mg
A derivative of lycorine with antihypertensive and neuroprotective activities; inhibits methoxamine-induced contraction of isolated rabbit aortic rings and rat anococcygeus muscle (pA2s = 5.93 and 6.35, respectively); reduces MAP in anesthetized and conscious normotensive rats at 80 mg/kg; reduces electrically or phenylephrine-induced hypertension in pithed rats; reduces infarct size, cerebral edema, and myeloperoxidase activity in a rat model of focal cerebral ischemia-reperfusion injury when administered following reperfusion
Cayman Chemical TalatIsamIn 10mg
A diterpene alkaloid with diverse biological activities; blocks IK current in rat hippocampal neurons (IC50 = 146 μM); reduces Aβ40-induced increases in IK current and cytotoxicity in primary rat cortical neurons; inhibits barium chloride-induced contractions in isolated rat intenstines (EC50 = 200 μM); exhibits feeding deterrent activity against red flour beetle (T. castaneum) adults (EC50 = 342.8 ppm)
Cayman Chemical ThIopropamInhydrochlorIde 10mg
An analog of amphetamine in which the phenyl ring has been replaced by a thiophene group
Cayman Chemical ElagolIxsodIum salt 10mg
An antagonist of GnRHR (Ki = 0.9 nM in a radioligand binding assay); selective for GnRHR over CYP3A4 (IC50 = 56 μM) as well as a panel of 100 receptors, ion channels, enzymes, and transporters (IC50s = >10 μM); inhibits GnRH-induced inositol phosphate production in RBL-1 cells expressing human GnRHR (IC50 = 1.5 nM); suppresses production of luteinizing hormone in castrated male cynomolgus macaques at 30 mg/kg
Cayman Chemical L-CarnItIn-d3chlorIde 10mg
An internal standard for the quantification of L-carnitine by GC- or LC-MS
Cayman Chemical ANTIBODYR-AS-1 10mg
A positive allosteric modulator of EAAT2 (EC50 = 11 nM in a glutamate uptake assay); selective for EAAT2 over EAAT1, EAAT3, and a panel of 30 other ion channels, transporters, receptors, and enzymes; increases spontaneous locomotor activity in mice at 60 and 90 mg/kg; has anticonvulsant activity in mouse models of seizures induced by MES, PTZ, or electrical stimuli of 32 or 44 mA (ED50s = 66.3, 36.3, 15.6, and 41.6 mg/kg, respectively)